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No use, distribution or reproduction is permitted which does not comply with these terms. Eosinophils have widespread procoagulant effects.
In daily practice, eosinophil-related cardiovascular toxicity consists of endomyocardial damage, eosinophilic vasculitis and arterial or venous thrombosis. Here we aim to report on the clinical features and treatment outcomes of patients with unexplained ophthalmic vascular manifestations and eosinophilia. Fifty-seven patients were included 20 from the observational study and 37 from the literature review.
The median [IQR] absolute eosinophil count at onset of ophthalmic vascular manifestations was 3. After a median follow-up of At the time of recurrence, absolute eosinophil counts were above 0. This study broadens the spectrum of vascular manifestations associated with hypereosinophilia by adding ophthalmic vascular manifestations.
In patients with ophthalmological vascular manifestations and hypereosinophilia, aggressive treatment of the underlying pathology and normalization of blood count should be implemented. Keywords: eosinophilia, hypereosinophilic syndrome, eosinophilic granulomatosis with polyangiitis, retinal artery occlusion, retinal vein occlusion, retinal vasculitis, optic neuropathy. Eosinophils have widespread effects. These include the production of procoagulant phospholipids and the production of tissue factor and activated factor XII, both of which promote the genesis of thrombin 2 โ 4.
