Official websites use. Share sensitive information only on official, secure websites. It is now established that patients with hyperlipidemia have a high risk of atherosclerosis and thrombotic complications, which are two important events responsible for the onset and progression of cardiovascular disease.
In the context of managing dyslipidemia by means of dietary advice based on the consumption of argan oil, we wanted to investigate the effect of virgin argan oil on plasma lipids, and for the first time, on the platelet hyperactivation and oxidative status associated with dyslipidemia. This study concerns patients recruited in the area of Rabat in Morocco. After a 3-week consumption period, blood total cholesterol was significantly lower in the argan oil group, as was LDL cholesterol Interestingly, in the argan oil group thrombin-induced platelet aggregation was lower, and oxidative status was enhanced as a result of lower platelet MDA and higher GPx activity, respectively.
In conclusion, our results, even if it is not representative of the Moroccan population, show that argan oil can prevent the prothrombotic complications associated with dyslipidemia, which are a major risk factor for cardiovascular disease. Cardiovascular disease CVD is the main cause of increasing mortality worldwide.
Dyslipidemia, the main risk factor for CVD, is a heterogeneous metabolic disorder involving multiple etiologies; it is commonly characterized by increased triglycerides, low-density lipoprotein LDL cholesterol and apolipoprotein B apo-B levels, and reduced plasma high-density lipoprotein HDL cholesterol [ 2 ].
These components of dyslipidemia confer an increased risk for atherosclerosis and thrombosis, which are two important events responsible for the onset and progression of CVD [ 3 ]. It is now established that patients with hyperlipidemia have a high risk of atherosclerosis and thrombotic complications [ 4 - 6 ]. Several mechanisms have been suggested by which alterations in plasma lipid levels may promote atherosclerosis [ 7 - 9 ].
