Metrics details. Method: A cross-sectional survey was distributed online and in-person to a cohort of Irish Athletes. Online version of survey was created using Google Docs. Participants: Irish Athletes, that are aged 16 or over, who participate in outdoor training or competitions.
Results: athletes completed the survey. The mean Knowledge Score for the cohort was 7. The mean Protection Score for the cohort was 3. In regard to scoring range, Pearson Chi-Square Test and Linear Regression were used to assess relationships between each category. Conclusion: This study highlights the importance of promoting skin cancer awareness amongst Irish Athletes and encouraging use of sun protection whilst training and competing. The study may be repeated in order to re-assess levels of awareness and encourage protection use, with the possibility of implementing an intervention such as a national awareness campaign.
Background: Unfolded protein response UPR is a coordinated program that helps cells to adapt to high levels of unfolded proteins in the ER to restore homeostasis.
UPR induces increased protein folding capacity and degradation of misfolded proteins to restore protein homeostasis. Recent evidence has shown significant discordant expression between intronic miRNAs and host genes.
There is increasing evidence of a connection between UPR and the development of breast cancer. The regulation of miR expression during UPR and its function in breast cancer is not clearly understood. DMSO was used as a control. Quantitative real time PCR was performed to examine gene expression. The data was analysed using SPSS Two-tailed unpaired t-test was used to determine statistically significant differences between independent groups.
